研讨会——一个系统nalysis of commercial e-liquids: The evolution of GRAS to Inhaled Toxins

Overview

Title:A systematic analysis of commercial e-liquids: The evolution of GRAS to Inhaled Toxins

Duration:1 Hour 23 minutes

Available On Demand

Summary

Electronic cigarettes (e-cigs) were originally developed as an alternate method for nicotine delivery, and the e-liquids consist of a range of humectant formulations, pharmacologically active ingredients, flavoring chemicals, volatiles, preservative chemicals, and other “enhancing” chemicals.  E-cigs have also been adopted for drugs  other than nicotine (DOTN), including cannabidiol (CBD) and tetrahydrocannabinol (THC). E-liquid manufacturers use chemicals that are generally regarded as safe (GRAS) for oral consumption, but formulations have not been heavily scrutinized by regulatory agencies. As such, e-liquid formulations have evolved as a result of vaping preferences, public health sentiment, and looming regulations.  The chemical composition of e-liquids has been evaluated since 2015, to include humectant formulations, pharmacologically active ingredients, flavoring chemicals, volatiles, preservative chemicals, and other “enhancements”, using TOF MS, HS-GC-FID, GC-MS, and LC-MS/MS. The e-cig industry has provided an aura of safety for consumers. However, the recent EVALI epidemic exposed the toxic nature of vaping while the e-cig industry has facilitated the public consumption of recreational drugs and the abuse of these substances by providing efficient drug delivery devices. 

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